Gamma Glutamyl Transferase in Impaired Glucose tolerance and type 2 Diabetes Mellitus

Aim: The current study was undertaken, 1. to compare serum levels gamma glutamy transferase in among three groups namely type II diabetes mellitus, impaired glucose tolerance and apparently healthy controls; 2. to measure the association of gamma glutamy transferase levels and the risk of type II diabetes mellitus by logistic regression and to detect the best cut-off value for gamma glutamy transferase in type II diabetes mellitus and impaired glucose tolerance by ROC curve. Materials and Method: The study was conducted at tertiary care hospital, Bagalkot, Karnataka, India. Under aseptic precautions 5 ml of fasting venous sample was collected and biochemical parameters FBS, PPBS, HbA1c, lipid profile, liver enzymes, serum gamma glutamy transferase were estimated. SPSS for window version; SPSS, 11.5 Inc, Chicago IL was used for statistical analysis. Results: Only gamma glutamy transferase and BMI could fit in the model, whereas raised gamma glutamy transferase was associated with type II diabetes mellitus with odds ratio of 1.37 (P<0.001), whereas in the presence of raised BMI, odds ratio was 1.44(P<0.008). Even in impaired glucose tolerance, raised gamma glutamy transferase was associated with OR of 1.55 (p<0.001). The best cut-off value for gamma glutamy transferase was 24.3 mg/dL, in both type II diabetes mellitus and impaired glucose tolerance. Conclusion: An increase in gamma glutamy transferase concentration within its physiological range is a sensitive and early biomarker for the development of impaired glucose tolerance and type II diabetes mellitus, with best cut-off value of 24.3 mg/dL.