Oxidative stress and antioxidant status in coronary artery disease patients before percutaneous transluminal coronary angioplasty

Introduction: Oxidant lead to cell death through apoptosis and necrosis. The effects of reactive oxygen radicals are balanced by the antioxidant action. The aim of the study was to assess oxidative stress and antioxidant status in coronary artery disease patients before percutaneous transluminal coronary angioplasty and in healthy controls. Materials and Method: 120 patients of coronary artery disease, before PTCA and 120 healthy controls were included in the study. Malondialdehyde (MDA), Superoxide Dismutase (SOD), Vitamin C, Creatine Phosphokinase total (Cpk total) and Creatine Phosphokinase-MB (Cpk-MB) levels were measured before PTCA in patents and in controls. Result: There were increased levels of MDA, Cpk-total and Cpk-MB, 9.42 ± 1.07 nmole/ml, 105.95 ± 45.44 U/L, 12.20 ± 6.03 U/L (p < 0.001, p < 0.001 & p > 0.05) respectively, however oxidative stress significantly increased in patients than that of controls. Activity of SOD was 3.19 ± 0.45 (p > 0.05) and Vitamin C was 0.88 ± 0.32 (p > 0.05), decreased in patients before PTCA as compared to controls. Conclusion: These findings suggest that cardial lipo peroxidation may be a common event following brief episodes of myocardial ischemia and support a role for antioxidant therapy in patients with ischemia heart disease.