Evaluation of coagulation profile in patients suffering with type-2 diabetes mellitus: A hospital based prospective study

Introduction: T2DM and its complications develop due to uncontrolled plasma glucose levels for long time. Long term hyperglycemia will cause glycation of various tissue proteins. It also affects the coagulation process and proteins involved in coagulation. The present study conducted to evaluate the coagulation profile in the T2DM with and without complications. Materials and Methods: This study was done in the Institute of Biochemistry, Madras Medical College, Chennai, Tamil Nadu during the period of Nov. 2008 to Dec. 2008. A total of 175 subjects were included in the study, 25 patients in group-I was considered control group. Group-II had T2DM patients without complications (n=50). Subjects with T2DM-nephropathy (n=50) were included in group-III. The group-IV (n=50) had T2DM with retinopathy. All subjects demographic data, glucose levels, lipid profile, urea, creatinine and coagulation profile were estimated and recorded. The data was analyzed by SPSS soft ware by using ANOVA. Results: More females were there in group-I and II and more males in group-III and IV. Group-II showed significant changes in glucose, lipid profile and coagulation profile levels compared to other groups. Conclusion: T2DM with complications and without complications patients showed changes in coagulation profile. Better knowledge is required about the coagulation profile in T2DM patients with complications.