C-REACTIVE PROTEIN LEVELS PREOPERATIVELY AND POSTOPERATIVELY EFFECT ON CARDIOVASCULAR SURGERY COMPLICATIONS

Objective: to determine the relationship between pre-operative C1 protein (CRP) and post-elective cardiac surgery complications, including atrial fibrillation, systemic inflammatory response syndrome, wound infection, acute renal failure, shock, and death. Materials and Methods: This prospective observational study was conducted at the Department of Cardiology Mayo Hospital, Lahore for the period of 1 year from December 2016 to December 2017. Patients who underwent cardiovascular surgery at CRP levels were measured in all patients in the morning following surgery. Patients were categorized as Group A (CRP <2 mg / dL) and Group B (PCR> 2 mg / dL) and hospitalization was followed by postoperative complications. Results: 140 patients (100 (70%) male and 40 (30% female) were studied; There were 97 (65.1%) patients with PCR <2 mg / dl (Group A) and 52 (34.9%) with PCR> 2 mg / dl (Group B). The average age in group A was 43.6 ± 13.2 years and in group B was 48.9 ± 13.4 years. The overall mortality rate in our study was 3.35% (n = 5). Systemic inflammatory response syndrome (SIRS) was 81 (54.4%); B group was 34 (65.4%) and 47 (48.5%) group (p = 0.048). Acute renal failure developed in 26 (50%) patients in group B and 28 (28.9%) in patients (p = 0.011). wound infections were observed in 13 (25%) patients and 11 (11.3%) in the high PCR from the low CRP group (p = 0.031). There was no significant statistically difference in atrial fibrillation and shock in both groups. Death rate was same in both groups. Conclusion: Preoperative high CRP levels may be postoperative complications such as SIRS, acute renal failure after elective cardiac surgery and wound infection. Keywords: C Reactive Proteins, Cardiovascular Surgery, Postoperative Complications.