Antioxidant and Toxicity Activity of Raru(Cotylelobium sp)Stem Bark

Research on natural medicinalplants has beengrowingdueto the increasing interestto natural medicinal material thatis consideredsafer than syntheticmedicines. In North Sumatera,bark ef Cotylelobiurn sp 1vhich is locallyknown as raru, has been 1videlyutilized f?y the localcommunity. The skin bark ef this species is commonly used as a mixtureef "nira" toproduce "tual:" (Batak'straditionalalcoholic liquor). In addition, localcommunityhas been usingthis species for traditional healing as we/L This research is to stutfy thepotenry ef ram's skin bark inproducing antioxidantusing DPHH method The toxicity activity of the materia! was also examined using Brine Shrimp Lethality Test (BSLT) method Results show that the yield extract of Cotylelobium melanoxylon Pierre was 30. 11% and Cotylelobium lanceolation Craibwas 14.50%.Both extracts containsjlavonoid, tamn, saponin, tnterpenoidand bidroqumon. The extractef Cotylelobi11111melanoxyton Pierre has antioxidant activity againstDPPH radicalwith valueef IC,0as much as 108.487 ppm and 77.909ppm for Cotylelobium lanceolatum Craib. Furthermore, the toxicity ef Cotyfelobium melanoxylon Pierrewas 643.550ppm and Cotylelobium lanceolatum Craib was 767.191 ppm LC