INFLUENCE OF NEUROINFLAMMATION ON DEPRESSIVE SYMPTOMS IN PARKINSON'S DISEASE

Introduction. Cytokines and cortisol participate in the implementation of complex functions of the central nervous system and play an important role in development of neurodegenerative and mental disorders. Goal. To determine a correlation of levels of IL-1β, IL-10 and cortisol in serum and cerebro-spinal fluid (CSF) with degree of depressive symptoms at patients with Parkinson Disease, measured with Hamilton Rating Scale for Depression. Material and methods. There were 31 patients of main group and 8 – control group. The study was approved by relevant ethical committees. We use non-parametrical methods of Statistics. Results. A wide prevalence of depressive symptoms in persons with PD was confirmed. There were found correlations between severity of depressive symptoms and age of PD onset, and levels of cytokines in serum and CSF. It is demonstrated prospects of further investigations. Conclusions. Neuroinflammation may participate in development of depressive symptoms at PD.