COMPARISON OF THE HEALING POTENTIAL OF PROPOLIS AND BEE VENOM ON SURGICALLY INDUCED WOUND IN RAT?S BUCCAL MUCOSA

Bee products include honey as well as propolis, royal jelly and venom which are used in medicine, not only as an immune system stimulant but also as a wound healing promoter. Aim of work: was to assess and compare the healing potential of propolis and bee venom on the healing wounds in rat?s buccal mucosa. Materials and Methods: Foutry five adult male Wistar albino rats divided into in 3 groups of 15 each (control, propolis & bee venom). A wound (3.5 mm diameter) was made in the cheek of each rat with a punch biopsy. Samples were prepared and investigated histopathologically and immunohistochemically by proliferating cell nuclear antigen (PCNA) after 1, 3 and 7 days of wounding. Results: Bee venom showed the highest healing potential followed by propolis through stimulated epithelial cells proliferation and reepithelization compared to the control group. Conclusion: Bee venom and Propolis had contributed positively to the wound healing in the surgically induced wounds of rat?s buccal mucosa.