THE ROLE OF BONE RESORPTION MARKERS IN EARLY DETECTION OF OSTEOPOROSIS IN PERIMENOPAUSAL WOMEN OF MANGALORE

Bone resorption markers are known to predicting the rate of bone loss in postmenopausal women . Many studies have shown that there is an increase in the bone resorption markers after menopause. The objective of the study was to study the markers of bone resorption in early detection of osteoporosis in perimenopausal women. A sample size of 150 individuals were chosen during a period of 2 years of which 50 were premenopausal women, 50 were postmenopausal women without fracture and 50 were postmenopausal with fracture. Early morning urine sample between 5am and 9 am was collected and taken after adding a preservative (HCL:5ml/l of urine). Urinary Hydroxyproline - (Modified Neuman Logan method) and Urinary calcium (arserazo method) were estimated. Results were expressed as mean SD and range values. ANOVA was used for multiple group comparisons. Relationship between variables was measured by Pearson's correlation co-efficient. Our study showed that mean values of Urinary hydroxyproline increased in postmenopausal women with fracture and without fracture when compared to the premenopausal women. This indicates that in this group there is more bone resorption . We conclude that biochemical markers of bone resorption are valuable tools of detecting osteoporosis as they reflect the activity level of the entire skeleton. . Hence early detection and prevention of osteoporosis will go a long way in improving the public health of the population , especially women .