Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Amlodipine Besylate and Candesartan Cilexetil in Synthetic Mixture

The present manuscript describe simple, sensitive, rapid, accurate, precise and economical q-absorbance method for the simultaneous determination of Amlodipine besylate and Candesartan cilexetil in synthetic mixture. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an Isoabsorptive point at 242 nm in Methanol. The second wavelength is used 255 nm, which is λmax of Candesartan cilexetil in Methanol. The linearity was obtained in the concentration range of 5-25 μg/mlof both drugs. The concentration of drugs was determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Candesartan cilexetil. The method was successfully applied to pharmaceutical dosage form because of no interference. The result of analysis has been validated by recovery studies.