Novel Nanotherapeutic Approaches for the Treatment of Emerging Multidrug Resistance

Realizing the high ability of multi-drug resistant fecal bacteria (MRFs) in developing resistance to every renewed conventional drug, alternative antimicrobials including natural nanocomponents have been explored. Synergism of the naturally occurring chitosan combined with Zinc Oxide (CZNPs) have been studied in our laboratories and has recently revealed an extraordinary antimicrobial potential against a broad spectrum of nosocomial MRFs. This article provides a condensed introduction on the most current knowledge of CZNPs properties including activities and selective toxicity. Potential effects of CZNPs on MRF strains in vitro and in vivo are also addressed.