FORMULATION AND IN VITRO EVALUATION OF ORO DISPERSIBLE TABLETS OF LORAZEPAM

The present investigation was done on lorazepam orodispersible tablets using super disintegrants. The prepared powder blend for all formulations was found to be within limits. Tablets were compressed using rotary tablet compression machine. Post compression studies like weight variation, hardness, thickness, friability, drug content, in vitro disintegration time were carried out which were found to be within limits. In vitro drug release studies revealed that Among all formulations F4 formulation were shown maximum drug release(99.99%) at 45 min. Among these three formulations F4 was considered as optimised formulation due to 2 mg of croscarmellose sodium. Key words: Lorazepam, Super disintegrants, Orodispersble tablets.