The Correlation between Malondialdehyde Level with Vitiligo Severity

Background: Vitiligo is an idiopathic disorder characterized by macular hypopigmentation due to melanocyte impairment and the absence of melanin production. There is an antioxidant-prooxidant ratio shift involved in oxidative stress. Malondialdehyde (MDA) is a stable product of lipid peroxidation and is a biologic marker of the increased oxidative stress. VASI is a parametric quantitative score that is sensitive to evaluate the degree of vitiligo severity. Objective: To determine the correlation between oxidative stress with vitiligo severity Methods: An analytical observational cross sectional study with consecutive sampling design Result and Conclusion: There is a positive and significant correlation (p=0.001; r=0.94) between MDA plasma level and the degree of vitiligo severity based on Vitiligo Area Severity Index (VASI).