Senescence Markers: One is not Good Enough, We Need More!

Senescence is considered as the response outcome generated in cells to halt the development and progression of tumor. The detection of senescent cells is problematic as there exists no exclusive marker of senescence that can be applied universally. In this review, we briefly describe the markers that are commonly used to identify senescent cells and also point out the limitations of their individual usage. We propose that rather than single marker, a combination of markers should be employed for faithful senescence detection and that increasing the available pool of senescence markers may facilitate senescence detection across different settings.