Increased Triglycerides and High Density Lipoprotein Ratio Associated with Progression of Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus

Dyslipidemia is a common occurrence in type 2 diabetes mellitus (T2DM) patients and plays the major role in accelerated risk of cardiovascular disease (CVD) and possible causes chronic kidney disease (CKD), the progression of which leads to end-stage renal disease. A total of 266 T2DM patients were categorized into 2 groups according to their TG/HDL-C ratio of 2.5 and <2.5. The comparison of the clinical characteristics in these 2 groups demonstrated that Glucose, HbA1c, total Cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) levels, TG/HDL-C ratio were significantly higher, while high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) were significantly lower in the group with TG/HDL-C ratio 2.5 (p<0.05). Multiple logistic regressions demonstrated elevated TG/HDL-C ratio associated with CKD and increased HbA1c. The ORs and 95 % CIs were 4.94 (2.45, 9.96), 2.29 (1.13, 4.65) after adjusting for their covariates. Elevated TG/HDL-C ratio was associated with CKD and HbA1c and may increase the rate of disease progression and predict decline in kidney function and structural damage in these T2DM patients.