In Vivo Assessment of Antihyperglycemic and Antihyperlipidemic Potential of Sesamum Indicum Oil in Streptozotocin Induced Diabetic Rats

Aims: In the present study the antihyperglycemic and antihyperlipidemic effects of oil from seeds of Sesamum indicum Linn. (SIO) were investigated. A streptozotocin-nicotinamide (STZ) rat model of hyperglycaemia was used to evaluate the antihyperglycemic and antihyperlipidemic properties of oil of linseed. Materials and Methods: The body weight, oral glucose tolerance test and biochemical parameters viz. glucose level, insulin level, liver glycogen content, glycosylated hemoglobin and lipid profile parameters were estimated for all treated groups and compared against diabetic control group. Results: SIO (500 mg/kg/day and 1000 mg/kg/day) in respective groups of diabetic animals administered for 28 days reduced the blood glucose level in streptozotocin-nicotinamide induced diabetic rats. There was significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose and glycosylated hemoglobin in test groups as compared to control group. Conclusions: The findings demonstrate that SIO have excellent antihyperglycemic and antihyperlipidemic activities and thus have great potential as a source for natural health products.