Urgent Need for Discovery of Natural Novel Topopoisons in Treatment of Virus Causing Cancerse

Viruses are the confusing very minute particles between the living and non living environment; however they are made up of either DNA or RNA surrounded by a protein coat. These minute particles having a capability to enter a living cell and “hijack” the cell's internal surroundings and can hijack the cell machinery to make more viruses. This can be done by replacing their own DNA (or RNA) with that of the host. This can leads to virus induced resistant cancer. Several viruses are associated with human cancer and these type of cancers are most dreadful and resistant, even the existed synthetics/isolates became useless in continuous use towards these human disasters known as virus induced cancers. However the growing scientific skills and knowledge developed vaccines to protect against these viral induced cancers, but these vaccines can help only to protect against infections but not kill virus or virus affected cancer cells. Hence there is a very much urgent need of novel molecules / drug leads/ combinatorial alternative approaches to treat these types of cancers targeting common molecular targets like topoisomerases. Even there are differences between eukaryotic and prokaryotic topoisomerases. No attempt was made whether these novel natural molecules already existed or newly discovered can work on these both human and viral topoisomerases. However this type of combined target therapy will be possible from nature only. Hence the researchers have to focus in this new dimension how natural phytoceuticals can work on these multiple topoisomerases. The current editorial mini review focuses briefly on these issues in treating virus induced cancers.