IMMUNOPATHOGENESIS OF ENTAMOEBA HISTOLYTICA AT NEWLY DIAGNOSED MALE PATIENTS, IN THE EASTERN REGION OF IRAQ

This study aims to investigate the effect of Entamoeba histolytica infection on the cellular immunity of the patients, through measuring the following immune markers: IL-1α, IL-2 and IL-8 during acute amoebiasis, and to find out the correlation of serological parameter with the severity of infection. The study included 110 individuals (male only), 55 patients were diagnosed with Entamoeba histolytica, and 55 cases as a healthy control group. Immune markers IL-1α, IL-2 and IL-8 were assessed throughout the course of the infection. Results showed elevated levels of IL-1α and IL-2 in patients group compared with the healthy control group (8.216? 1.656) and (4.263?1.128) respectively (P <0.001). In addition, results showed a significant increase in IL-8 (P <0.001) with a confidence interval of (3.512-4.881).