Glycogen Synthase Kinase-3β (GSK-3β) is a Critical Factor in Intracellular Signaling Pathways in Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a common hematologic malignancy in children, teenagers, and young adults. The ALL development is a complex process, it includes the aberrant gene expression and the presence of chromosomal translocations. Chromosomal rearrangement have incidence in the cell maturation, proliferation and survival process. The treatment of ALL has shown high rates of effectiveness; however, the expression of biomarkers associated with the activation of cell signaling pathways is crucial to establish the prognosis of the disease. Glycogen synthase kinase-3β (GSK-3β) is a member of the serine/tyrosine kinase family with an important role in intracellular pathways signal; the GSK-3β transposition has been associated with changes in the transcriptional activity of nuclear factor kappa B (NF-kB) in blast cells. Nonetheless, others intracellular signaling pathways associated with the GSK-3β activity should participate in the ALL development.