MULTIPLE SCLEROSIS PLAQUES REGIONAL DISTRIBUTION VARIATION IN CANADA AND PAKISTAN WITH REFERENCE TO GREY & WHITE MATTER: A RETROSPECTIVE ANALYSIS CARRIED OUT AT SERVICES HOSPITAL, LAHORE

Background and Purpose: The retrospective determination of the involvement of the regional variation in the establishment of the MS cases of in Canada and Pakistan in term their population. Our research also analysis the para hippocampal gyrus lesions in its detailed characterization as per the distribution of the grey white matter. Methods: Sixty cases were presented through clinical assessments having multiple sclerosis, they were made a part of this research. Total sample was divided in to two groups having thirty patients in each group from the population of Pakistan and Canada. The process of imaging was carried out on the (1.5 T MR system) with T1 – W, T2 – W, FLAIR, Proton density and T1W sequence of post-gadolinium. The count of the lesions was made and they were categorized in the light of anatomic regions para ventricular, juxta cortical and temporal lobe. The involvements of the juxta cortical of para hippocampal area in the consideration of the involvement of the brain parenchymal were also categorized. This retrospective research was carried out at Services Hospital, Lahore from 21 April, 2016 to 30 June, 2017. Results: More incidence of disease was observed in the Canadian population when compared to the population of Pakistan with a mean younger than the Canadian population; however, the the distribution of the anatomical lesions in temporal lobe, Para hippocampal and paraventricular region almost the same in both the nations. Conclusion: In the Canadian population it was observed that most common was the multiple sclerosis; however, its distribution of the anatomical lesions including the para-hippocampal area was not significantly involved in the variation. Keywords: Periventricular (PVC), Multiple sclerosis (MS), Juxta cortical (JC), Temporal lobe and Para-hippocampal.