Ziziphus Joazeiro Martius and Ketoconazole added to Acrylic Resin Present Antifungal Activity

C. albicans has been shown to be associated with denture-related stomatitis. This study aimed to evaluate the antifungal effect of a hydroalcoholic extract of Ziziphus joazeiro Martius (HEZJM) and ketoconazole. Ninety specimens were used, 10 in each group: GROUP I – 1% of the polymer replaced by HEZJM; GROUP II – 2% of the polymer replaced by HEZJM; GROUP III – 1% HEZJM added to the polymer; GROUP IV – 2% HEZJM added to the polymer; GROUP V - control group; GROUP VI – Polymer replaced by 1% ketoconazole; GROUP VII – polymer replaced by 2% ketoconazole; GROUP VIII – 1% ketoconazole added to the polymer; GROUP IX – 2% ketoconazole added to the polymer. The specimens were placed on plates containing Sabouraud agar with Candida albicans. Plates were then kept in a bacteriological incubator at a temperature of 37°C for 48 hours. In groups I and II, specimens were not colonized. In groups III and IV, there was no inhibition zone or adherence of colonies. In group V, the surfaces of five of the ten specimens were colonized. In group VI, all specimens showed fungi static action. Group VII presented three specimens that formed halos of inhibition and four specimens that altered the growth pattern of the colonies. Group VIII altered the growth pattern of two specimens. In group IX, colonization of the specimens did not occur. The authors concluded that in the tested specimens there was no colonization of the surface, and replacing the polymer with 2% ketoconazole showed the best results.