Design and Experimental Analysis of a Cetirizine Hydrochloride Drug Sensor

A cetirizine hydrochloride PVC membrane drug sensor was developed by using the ion association complex produced with sodium tetra phenyl borate and cetirizine hydrochloride as electroactive substance. In sodium dihydrogen phosphate-sodium hydroxide buffer solution of pH 5.0, the linear range of the sensor is 1.58×10-6~1.0×10-1 mol/L, the slope is 46mV/pC (20°C) and the detection limit is 6.31×10-7 mol/L. The sensor has fast response and good reproducibility. Using the sensor for the determination of cetirizine hydrochloride in drugs, the relative standard deviation is less than 3% and the results are consistent with the labeled content in preparations.