Comparative Evaluation of Branded and Generic Medicines - Ranitidine & Metformin HCl

Ranitidine is H2 receptor antagonist used to treat Duodenal ulcers, Metformin HCl is Biguanide Antihyperglycemic agent used used for treating non-Insulin dependent Diabetes Mellitus (NIDDM) and as anti-diabetic used for the treatment of Type-2 Diabetes Milletus. The present study was to compare and evaluate the Quality and Price of Ranitidine and Metformin HCl Branded and Generic medicines. The selected Branded and Generic tablets are coded as C1, C2, C3, C4. Each tablets were evaluated for evaluation parameters such as Weight variation, Hardness, Friability, Disintegration, Assay, in-vitro Dissolution. From the results based on the Evaluation tests of Tablets and invitro dissolution rate studies, the Branded Medicines showed better Drug release and followed First order kinetics of Drug Release.