Novel Carboxymethyl Chitosan-β-Cyclodextrin Nanoparticles as a Drug Delivery System; Preparation and Characterization.

The aim of this study was to generate a new type of nanoparticles made of carboxymethyl chitosan (CMC) and carboxymethyl β-cyclodextrin (CM β-CD) and to characterize it. This nanoparticulate system should have a potential for the association and delivery of hydrophilic and hydrophobic drugs as well as undergo further conjugation to other macromolecules such as antibodies for targeted delivery especially in cancer therapy. Various CMC concentrations and a fixed concentration of CM β-CD were processed to nanoparticles via the ionic gelation technique by grafting the CM β-CD onto CMC using water-soluble 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as the condensing agents. The resulting nanoparticles were spherical in shape as shown by atomic force microscopy with an average size range of 124?298 nm and showed a negative zeta potential ranging from -7.9 to -33.7 mV.FTIR studies confirmed the successful synthesis of the nanoparticles by identifying the possible interaction between the various components of the nanocomplex.