Biomarker of Myocardial Stress sST2 in Patients with Acute Myocardial Infarction with ST-Segment Elevation

The purpose of the study was to determine the associations between sST2 and clinical-anamnestic, morphofunctional and biochemical factors, which can influence on acute myocardial infarction with ST-segment elevation (STEMI) and after infarction period. Materials and methods. 103 patients with STEMI were examined, 75 (72,8%) men and 28 (27,2%) women, at the average age (61,85±12,23). The level of sST2 was determined by immunofermentative method with «Presage ST2 Assay», Critical Diagnostics, USA reactives. Statistics was obtained thanks to software package Statistica 8.0 (Stat SoftInc, USA), Microsoft Office Exсel 2003. Results and discussion. Women had higher level of sST2 than men (р=0,04). Moreover, sST2 level was significantly higher in woman before 60 years old compared with men of the same age (р=0,031). The absence of significant differences in sST2 levels in men and women after 60 years old (р=0,671) equalizes both sex to cardiac remodeling. Higher level of sST2 was revealed in patients with glomerular filtration rate (GFR) less than 60 ml/min/1,73 m2(р=0,024). Positive correlation between sST2 and blood creatinine (r=0,37, P=0,001), and negative – between sST2 and GFR (r=-0,35, P=0,0001) were revealed. Positive correlation was determined between sST2 and patients age (r=0,27, P=0,007), left atrium diameter (r=0,27, P=0,01), end systolic volume (r=0,35, P=0,001), end diastolic diameter (r=0,24, P=0,02), end systolic diameter (r=0,33, P=0,001), negative correlation with systolic arterial pressure (r=-0,25, P=0,009), diastolic arterial pressure (r=-0,20, P=0,04), left ventricular ejection fraction (r=-0,36, P=0,0001). Conclusions. Positive correlation between sST2 and cardiogemodynamic data reveals about early left ventricular remodeling. High level of sST2 in women confirms their vulnerability to ischemic injury. The association between sST2 in patients with STEMI and kidney dysfunction confirms their injury in acute period of STEMI.