Inhibition of CCR5 and CXCR4 prevents HIV infection
Journal: Bioresearch Communications (BRC) (Vol.03, No. 01)Publication Date: 2017-01-02
Authors : Eric Matamoros;
Page : 326-339
Keywords : Chemokine receptors; HIV infection; inhibition; gene therapy; gene editing tools;
Abstract
CCR5 and CXCR4 are chemokine receptors recognize by HIV to enter into the host cell. In this review, we focus on their biology, function and pivotal role in HIV-1 infection, and also, how HIV quasi-species change tropism depending on their expression on the cell surface. We also discuss about the state-of-the-art strategies for targeting CCR5 and CXCR4, with emphasis on novel gene therapies that mimic a natural mutation called CCR5-delta32, enabling innate protection against HIV R5 strains. Trials with gene therapies can knockout both co-receptors and confer protection in vitro without mutants. These techniques include zinc finger nucleases (ZFN), clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9 nuclease (CRSIRP/Cas9), transcription activator-like effectors nuclease (TALEN), short hairpin RNA (shRNA), and ribozymes.
Other Latest Articles
- Garo Population of Bangladeshi Hilly Region Possesses Higher Frequency of ACE I/I Genotype in Angiotensin-converting Enzyme-1 (ACE-1) Gene
- Absorption of Water and Electrolytes from a Liposome Based Oral Rehydration Solution: An in vivo Perfusion Study on Mucosal Injured Small Intestine Rat Model
- Isolation and Characterization of Lactic acid Bacteria from Indigenous Dairy Product and Preparation of Starter Culture by Freeze-drying
- Report on Mycoflora associated with infected stems and capsules of Nigella sativa L. (Black Cumin)
- Network and pathway analysis for Cesium in Homo sapiens
Last modified: 2018-08-13 16:36:43