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Inhibition of CCR5 and CXCR4 prevents HIV infection

Journal: Bioresearch Communications (BRC) (Vol.03, No. 01)

Publication Date:

Authors : ;

Page : 326-339

Keywords : Chemokine receptors; HIV infection; inhibition; gene therapy; gene editing tools;

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Abstract

CCR5 and CXCR4 are chemokine receptors recognize by HIV to enter into the host cell. In this review, we focus on their biology, function and pivotal role in HIV-1 infection, and also, how HIV quasi-species change tropism depending on their expression on the cell surface. We also discuss about the state-of-the-art strategies for targeting CCR5 and CXCR4, with emphasis on novel gene therapies that mimic a natural mutation called CCR5-delta32, enabling innate protection against HIV R5 strains. Trials with gene therapies can knockout both co-receptors and confer protection in vitro without mutants. These techniques include zinc finger nucleases (ZFN), clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9 nuclease (CRSIRP/Cas9), transcription activator-like effectors nuclease (TALEN), short hairpin RNA (shRNA), and ribozymes.

Last modified: 2018-08-13 16:36:43