A Unique Case of Primary Hepatic CD30-Positive, CD15-Negative Classical Hodgkin’s Lymphoma Presenting as Fever of Unknown Origin and Acute Hepatic Failure

Hodgkin's lymphoma is a B-cell lymphoproliferative neoplasm that commonly presents with lymphadenopathy and constitutional symptoms. Primary Hodgkin's lymphoma of the liver without extrahepatic lymphadenopathy is rare, representing about 0.016% of all non-Hodgkin's lymphoma and 0.4% of all extranodal lymphomas. Most primary hepatic lymphomas (PHL) are of the diffuse large B-cell histology. In a patient presenting with fever and acute hepatic failure in the absence of extrahepatic lymphadenopathy, the diagnosis of primary Hodgkin's lymphoma should be entertained. To our knowledge, this is the first reported case of CD30-positive, CD15-negative primary hepatic classical Hodgkin's lymphoma.