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Alteration of the Methylation Status of Urokinase Plasminogen Activator (uPA) is involved in Proliferation and Invasion of Nasopharyngeal Cancer Cells

Journal: Archives of Otolaryngology & Rhinology (Vol.1, No. 1)

Publication Date:

Authors : ; ;

Page : 023-027

Keywords : ;

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Abstract

The extracellular matrix degradation is the most important step in the process of tumor cell metastasis. Urokinase-type plasminogen activator (uPA) can catalyzes the conversion of the inactive zymogen plasminogen to the active broad-spectrum plasmin, which degrades a number of matrix proteins and also activates other proteases, including some matrix metalloproteinases.

Last modified: 2018-08-31 19:33:35