Alteration of the Methylation Status of Urokinase Plasminogen Activator (uPA) is involved in Proliferation and Invasion of Nasopharyngeal Cancer Cells
Journal: Archives of Otolaryngology & Rhinology (Vol.1, No. 1)Publication Date: 2015-08-26
Authors : Ju-Hong Yang Chun-Sheng Lu; Song Zhang;
Page : 023-027
Keywords : ;
Abstract
The extracellular matrix degradation is the most important step in the process of tumor cell metastasis. Urokinase-type plasminogen activator (uPA) can catalyzes the conversion of the inactive zymogen plasminogen to the active broad-spectrum plasmin, which degrades a number of matrix proteins and also activates other proteases, including some matrix metalloproteinases.
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