Analysis of Risk Factors for Development of Hepatocellular Carcinoma in Chronic HBV - Infected Liver Cirrhosis Patients: A Meta-Analysis

The 5-year cumulative incidence rate of hepatocellular carcinoma (HCC) in chronic HBV -infected liver cirrhosis (LC) patients was up to 5%-30%. However, existing medical interventions can't cure chronic HBV -infected LC patient. At present, the association between risk factors and development of chronic HBV -infected HCC have been explored by previous studies, but the results remains inconsistent. We took the chronic HBV -infected LC patients as the research object. We systematically searched for studies evaluating whether those proposed factors changed HCC risk from Chinese Medical Journal Database, Chinese National Knowledge Infrastructure, Pubmed, Elsevier, Springer, Wiley, OVID, EBSCO in BoKu data service platform. Odds ratios (OR) with 95% confi dence intervals (CI) were calculated by Review Manager 5.0. In this meta-analysis, 1088 cases and 602 controls from 6 studies were included.