Mediastinal Tuberculosis Lymphadenitis during Anti-TNF Therapy - Case Report
Journal: Archives of Clinical Gastroenterology (Vol.1, No. 2)Publication Date: 2015-10-14
Authors : Bruno Cesar da Silva Fabio Carneiro Vosqui Nascimento Sonyara Rauedys Oliveira Lisboa Eduardo Antonio Gonçalves Ramos Valdiana Cristina Surlo Tatiana Senna Galvão Nonato Alves; Genoile Oliveira Santana;
Page : 038-040
Keywords : Inflammatory bowel disease; Anti-TNF; Tuberculosis;
Abstract
Tuberculosis is described during the use of monoclonal antibodies against tumour necrosis factor (TNF) for Crohn's disease treatment. We report a case of a 44 year old man that developed fever, night sweats and weight loss during immunosuppressive and anti-TNF therapy for Crohn's disease. After extensive investigation we performed mediastinoscopy with biopsy of the paratracheal lymph node. A istopathological study revealed caseous necrosis. The patient improved after therapy against tuberculosis. During anti-TNF therapy, the diagnosis of tuberculosis may be mainly difficult when an atypical location is present. Clinical skills are important mainly in countries where tuberculosis is endemic.
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