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Mediastinal Tuberculosis Lymphadenitis during Anti-TNF Therapy - Case Report

Journal: Archives of Clinical Gastroenterology (Vol.1, No. 2)

Publication Date:

Authors : ; ;

Page : 038-040

Keywords : Inflammatory bowel disease; Anti-TNF; Tuberculosis;

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Abstract

Tuberculosis is described during the use of monoclonal antibodies against tumour necrosis factor (TNF) for Crohn's disease treatment. We report a case of a 44 year old man that developed fever, night sweats and weight loss during immunosuppressive and anti-TNF therapy for Crohn's disease. After extensive investigation we performed mediastinoscopy with biopsy of the paratracheal lymph node. A istopathological study revealed caseous necrosis. The patient improved after therapy against tuberculosis. During anti-TNF therapy, the diagnosis of tuberculosis may be mainly difficult when an atypical location is present. Clinical skills are important mainly in countries where tuberculosis is endemic.

Last modified: 2018-09-04 14:12:58