“C” Trouble: Class IC Anti-arrhythmic Toxicity

The most common cardiac arrhythmia encountered in clinical practice is atrial fibrillation (AFib). AFib has significant effects on long-term mortality and stroke, and contributes greatly to overall healthcare costs, affects quality of life and the functional status of many patients [1]. The incidence and prevalence of AFib continues to rise with age, when comorbidities that affect rhythm management frequently coexist [1].