Study of uric acid and lipid profile in recent onset essential hypertension

Introduction: Hypertension is a major public health problem. Uric acid is emerging as one of the strongest risk factors for hypertension. Alteration in lipid profile has been identified as independent risk factor for hypertension. Aim:The aim of our present study was to determine the association of uric acid and lipid profile with hypertension of recent onset. Materials and Methods: 45 subjects with age group between 20-50 yrs with recent onset essential hypertension were taken as test group. Control group comprised of 45 healthy, age and sex matched controls satisfying the exclusion criteria. Serum Uric acid, TC, HDL-C,LDL-C, TG'S were determined by enzymatic methods using commercially available kits on a fully automated analyzer. VLDL was a calculated parameter. Results:In the test group the mean uric acid levels in males and females were 6.1 ± 0.78 mg/dl and 5.5 ± 0.93 mg/dl respectively. The mean uric acid levels among males and females in the control population was 4.2 ± 0.81 and 4.1± 0.56 mg/dl respectively. A significant difference in uric acid levels between the test group and control group both among males (p= 0.039) and females (p= 0.041) was observed. Among the lipid profile parameters. The mean Total cholesterol and Triglycerides were high in cases as compared to controls with p-values of 0.046 and 0.038 respectively. In test group higher mean values for HDL – C, LDL-C, VLDL were found as compared to controls but the increase was not statistically significant. Conclusion: A significant association of UA with Hypertension both among males and females was observed in our study. Among the lipid profile parameters a significant association was found between Total cholesterol, Triglycerides and hypertension.