INFLUENCE OF EPOETIN ALFA ON LEVEL OF PROINFLAMMATORY AND ANTIINFLAMMATORY CYTOKINE OF PATIENTS IN MAINTENCE HEMODIALYSIS
Journal: Ukrainian Journal of Nephrology and Dialysis (Vol.2, No. 42)Publication Date: 2014-05-30
Authors : I. Dudar; Y. Gonchar; V. Savchuk; I. Shifris; O. Loboda;
Page : 14-19
Keywords : anemia; chronic kidney disease; hemoglobin; cytokine; chronic inflammation; epoetin alfa;
Abstract
The aim of the present research was to study the influence of еpoetin alfa to the level of pro- and anti-inflammatory cytokines in patients with anemia treated by hemodialysis (HD). Materials and methods: We examined 73patients with anemia treated by hemodialysis (mean age 45,85 ±1,21 years). Patients were divided into 2groups: I group - comparison (n = 32), II group - treatment by epoetin alfa (n = 41). The levels of hemoglobin, C-reactiveprotein, ferritin, albumin, pro-and anti-inflammatory cytokines were determined before and after treatment in patients of both groups. The duration of treatment was 5 months. Results: Epoetin alfa increases Hb levels in patients treated by HD. After epoetin alfa applying reduction of proinflammatory cytokines ( TNF -a, IL -ip, IL -17, IL -18) and increased levels of IL -10 were observed. Conclusions: The clinical efficacy of the epoetin alfa treatment at the moment of completion of treatment was 75.6% (level of Hb > 110 g/L ). Epoetin alfa, improving the level of Hb, reduces the activity of chronic inflammation.
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