THE CORRELATION OF SERUM S-100 PROTEIN LEVEL WITH THE SEVERITY OF STROKE

The objective: This study investigated correlation between the level of serum S-100 protein, stroke subtype and stroke severity using the National Institute of Health Stroke Scale (NIHSS) of the patients admitted to the Institute of Emergency Medicine, Neurology Department, Chisinau, Republic of Moldova, and diagnosed with an ischemic stroke. The methods: Blood were collected from the patients (n = 39) to determine S-100 protein level, age and sex-matched healthy individuals (n = 39) served as control. All patients had cranial computerized tomography scan in the first 24 hours. The neurological evaluation was made with the National Institute of Health Stroke Scale (NIHSS) in the acute stage. The results: Compared with controls, S-100 protein level were significantly higher in the stroke group. Conclusion: Serum S-100 protein measurement can be used as an early marker of brain damage. There is a role of S100 protein as a co-predictor of outcome in patients with acute stroke