Synthesis and Characterization of Some Isoxazole derivatives for Antimicrobial Activity

In the present work, some newer 3,5-substituted diphenyl isoxazole derivatives (compounds 1-10) were synthesised by reaction of hydroxylamine hydrochloride with various freshly synthesised 1-(substituted phenyl)-3-(substituted phenyl)prop-2en-1-one derivatives (compounds. 1A-10A) in the presence of pyridine and catalytic amount of sodium hydroxide. Compounds 2, 4, 5, 10 were found to possess good antibacterial activity and compounds 3 and 10 showed good antifungal activity when compared with standard drugs ciprofloxacin and fluconazole at the concentration 50 μg mL-1. These results suggest that the synthesized isoxazole derivatives exhibit promising activity and this work may pave the way for future development of promising compounds for this purpose.