Recent Advances, Patent Scenarios and Future Developments on Gastro-Retentive Drug Delivery System: A Patent Overview

Pharmaceutical industries have received much interest in pharmaceutical research in the area of oral drug delivery. Oral administration of drug is the most convenient and versatile way due to the simple and comfortable use and flexibility concerning dose strength, and type of formulation. GRDDS is an approach to prolong gastric residence time, thereby targeting site-specific drug release in upper GI tract improving the oral sustained delivery of drug that have an absorption window in a particular region of the GI tract. These systems help in continuously releasing the drug before it reaches the absorption window, thus ensuring optimal bioavailability. This manner may increase patient compliance and provides continuously controlled release administration of sparingly soluble drugs at the particular sites of absorption. More than 55% of drug available in the commercial market used for orally. During the last five decades, little oral delivery has been produced to act as a drug reservoir from which the active ingredients are specified period of time released and at controlled the release rate. Method for preparing GRDDS is simple and straight forward, and as a result economically attractive. An assortment of approaches for gastric retention are floating, non-floating, swelling, bioadhesive, magnetic controlled, and dual working systems etc. This patent overview summarizes the recent marketed approach, patents scenario and future aspect of the GRDDS. This patent outline is also provides the information of oral GRDDS intended for its application.