Pre-Ankylosing Spondylitis State

Ankylosing Spondylitis (AS) is a chronic inflammatory systemic disorder belonging to the SpondyloArthridies with axial joint involvement and enthesitis, with or without peripheral arthritis and systemic involvement. We know that AS has a strong genetic background especially HLA-B27 positivity and familial aggregation. HLA-B27 positivity and positive family history of AS and other SpondyloArthritidies can increase the chance of occurrence of AS. This chance in monozygot twins is more than dizygot and in first degree family is more than second degree. There are individuals who are not affected by AS currently but have the risk of progression towards AS in the future. This condition is called “Pre-Ankylosing Spondylitis state”. The author of this letter wants to introduce and do