First Day (24±2hr) Serum Bilirubin Level, as Predictor of Significant Hyperbilirubinemia in Neonates

Background: Age-specific (24±2hours) predictive value of total Serum Bilirubin (TSB) ≤ 6 mg/dl in developing significant hyperbilirubinemia in infants Methods: A Prospective observational study on 200 term neonates having birth weight ≥2500 gm and gestational age ≥37 weeks. Blood was collected from the venous site. The blood samples of all infants were sent for grouping and TSB estimation. Babies were clinically examined every day for jaundice. Whenever jaundice was clinically noticed to be >10 mg/dl, bilirubin estimation was repeated immediately and then every day till 5 days of age and the highest reading was recorded as peak TSB. Results: Significant hyperbilirubinemia (>17mg/dl) was present in 13% cases. At 24±6hours TSB >6 mg/dl was present in 47 cases and 26 of these developed hyperbilirubinemia (≥17 mg/dl) and TSB ≤6mg/dl was present in 153 cases, 2 of them developed significant hyperbilirubinemia. The incidence of hyperbilirubinemia in babies whose mothers received oxytocin and those whose mothers did not receive oxytocin was 19.6% and 8.2% respectively. The difference was highly significant. The mean values of TSB at 24±2 hrs in oxytocin used and oxytocin not used groups were 3.94±2.15 mg/dl and 3.36±1.91 mg/dl respectively, the difference was statistically significant but mean values of Peak TSB in oxytocin used and not used groups were. 12.78±4.28 mg/dl and 12.03±3.42 mg/dl respectively which was statistically not significant. Conclusions: Incidence of significant hyperbilirubinemia in healthy babies is 13%. Use of oxytocin increased its incidence. TSB at 24±2hours ≤6mg/dl has a high predictive value in identifying those infants who are unlikely to develop subsequent hyperbilirubinemia. This study, thus, will help to discharge healthy term infants with TSB on 2nd day ≤6mg/dl.