A rare case of Combined Protein C and Protein S deficiency Manifesting as Cortical venous thrombosis

Protein C deficiency is a rare disorder that usually presents with purpura fulminans in the neonatal period ,disseminated intravascular coagulation and recurrent thrombotic episodes at a later age. Protein S deficiency is very rare. The annual incidence of cerebrovascular disease in children is 2.5 per 100,000 and cerebral infarction is being increasingly recognised in neonates. Here we see a case report of 11 months old child with combined Protein C and S deficiency presenting with hemiplegia due to Cortical venous thrombosis.