IMPROVEMENT OF SURGICAL TREATMENT FOR PRIMARY INGUINAL HERNIAS BY APIMPROVEMENT OF SURGICAL TREATMENT FOR PRIMARY INGUINAL HERNIAS BY APPLI-CATION OF MODIFIED PRE-PERITONEAL ALOHERNIOPLASTY TECHNIQUE

The article has established benefits of modified laparoscopic techniques of preperitoneal alohernioplasty without fixation to the preperitoneal space with the reconstruction of the preperitoneal flap defect with welding technology. Reduction of surgery duration, length of hospital stay and recovery period with a decrease in the need of analgesic administration in the postoperative period compared with open inguinal Lichtenstein alohernioplasty was demonstrated. High-frequency welding of the peritoneum edges determined to be safe and a reliable method of preperitoneal space closure in experiment. Results and discussions. A significant difference in the mean length of hospital stay and period until regaining the ability to perform professional tasks was noticed by comparing the average data obtained by analysis of variance using F-test. The length of hospital stay was reduced by 4.2 times and the period until restoring the ability to perform professional duties by 3.4 times in the group where a new surgical method had been applied. No significant difference in the levels of postoperative complications (3.85 and 5.77%; p = 0.036) and reoperation due to complications (0 and 0.96%; p = 0.023) was found. A significant difference in terms of pain at rest (3.19 and 6.38%; p <0.001), pain at exertion (7.44 and 11.28%; p <0.001), chronic pain that needed treatment (2.31 and 3.83%; p <0.001), recurrence levels (0 to 3.85%; p <0.001) was observed. Cox-regression analysis of the risk of bleeding showed that the occurrence of this complication was associated with chronic administration of anticoagulants (warfarin, sincumar) and antiplatelet agents (aspirin-containing drugs) due to the presence of comorbidities (p <0.001). The multivariate analysis determined that the type of surgery (Liechtenstein against the proposed surgical method) is an independent risk factor for recurrence of inguinal hernia (OR - 1.775, 95% CI -0.549 - 2.093) and chronic inguinal pain (OR - 1.420, 95% CI -1.335 - 1.596). High BMI and medial hernia according to EHS classification were also among the main risk factors for recurrence. No case of the non-fixed 3D Bard™ mesh migration was registered. The use of anatomically conformed prosthetic mesh implantation in preperitlneal space and the closure of peritoneal flap by high-frequency welding resulted in reduction of the need for analgesics in the early postoperative period (p˂0.001) and risk of long-lasting inguinal pain (p˂0.001). In experimental animals, the inflammatory reaction around the welded suture of the peritoneum demonstrated no statically significant increase of adhesion formation risk (p˃0.05) and reduction of the number of living mesotheliocytes was not associated with increased expression of inflammatory response (p˂0.001). The degree of fibrosis in the connecting line was higher in welding suture than in ligated, which provided greater tissue strength. Thus, the admissibility of the method of biological tissue welding for peritoneal defect closure due to its reliability, efficiency and safety was established. Conclusions and prospects for further studies. 1. The modified laparoscopic preperitoneal alohernioplasty for primary inguinal unilateral hernias that includes anesthesia of trocar wounds, terminal anesthesia of peritoneum and diaphragm, peritoneum hydropreparation for dissection of preperitoneal space, implantation of anatomically conformed mesh prosthesis without fixation and reconstruction of the peritoneal defect by electric welding is an effective and reliable technique in terms of the level of perioperative complications, quality of life of patients in the short- and long-term periods after surgery and the risk of recurrence. 2. Macroscopic and morphological changes of the peritoneum at different time points after the intervention in patients after the use electric welding require further studies.