CURRENT PROBLEMS OF TREATMENT AND MODIFI-CАTION OF CHRONIC OB-STRUCTIVE PULMONARY DI-SEASE

The article contains literature review on the problems of treatment of chronic obstructive pulmonary disease. Recommendations "Global Strategy: diagnosis, treatment and prevention of COPD (GOLD), European Respiratory Society (ERS) and a protocol of care for diagnosis and treatment of COPD are presented. The importance of using modern technologies in the treatment of chronic obstructive pulmonary disease is highlighted. Inhalation therapy as one of the most commonly used methods of treatment for patients with bronco-obstructive pathology is used to create the necessary concentration of medicinal substance in a certain area of the respiratory tract, providing local activity of the drug, minimal accumulation of drugs in other organs and systems of the organism. In this way, maximum efficacy is achieved with minimal pharmacological costs and side effects, since it is precisely inhalation systems that provide the optimum opportunity for the delivery of therapeutic agents directly to the respiratory system of the patient. The world medical community, having analyzed the experience of the last decades, came to the conclusion that the main principles of treatment of patients with chronic obstructive pulmonary disease are the regularity and continuity of the basic therapy according to the severity of the disease; gradual increase in the intensity of treatment depending on the severity of the course of the disease; the variability of the individual selection of treatment programs, depending on the response to treatment, which is determined by careful monitoring of the clinical and functional features of the disease. The rapid evolution of pulmonary pathology and the unstable development of the pharmacological industry make it necessary to further conduct modern research on the interaction of sanogenetic systems for the protection of the macro organism in conditions such as aggression of pathological exogenous and endogenous factors and adaptation to them. The present conditions put forward to the medical community (pulmonologists, therapists, family physicians, etc.) the task of using well-balanced, scientifically substantiated and consolidated programs for the diagnosis of COPD in the early stages, when the rate of progression of the disease is significantly reduced. Due to the multi-vector of its influence on the various pathogenetic mechanisms of development of the pathological process, tiotropium bromide, being a means of basic therapy, is able to manifest itself not only as prolonged bronchodilator, but also to show other manifestations of its application.