RESEARCH OF THE POLYMORPHISM OF TOL-TYPE RECEPTOR GENES 1 TLR1-I602S IN PATIENTS WITH ALERGO-DERMATOSIS

To investigate the polymorphism of the TLR-1-I602S tumor receptor gene in patients with allergic dermatitis. Materials and methods. The study of polymorphism of the TLR 1-I602S gene was performed in 39 patients, including 9 patients with atopic dermatitis(AD), 11 patients with true eczema (TE) and 19 patients with microbial eczema(ME) by polymorphism Johnson CM Restriction Lengths et al. The results of the experiment. In patients with allergic dermatoses (AD, TE, ME), genotype SS was detected in 12 (30.8%) cases, genotype IS - in 23 (59.0%) cases, and genotype II - 4 (10.2% ) cases, that is, the less active variants of the TLR1-I602S genotype prevail over the abandonment of the distribution of genotypes in the control group, in which the active genotype II-27 (65.8%) cases prevailed; The least active genotype SS was detected in 5 (12.2%) and the genotype IS was 9 (22.0%) cases (the difference in TLR1-I602S gene polymorphism in patients with AD, TE, ME was statistically significant compared with the control group χ2 = 26,038, p <0.001). In patients with BP, the active genotype of the TLR1-I602S II gene was not found, genotype IS was detected in 7 (77.8%) cases, and genotype SS - in 2 (22.2%) cases. In the true eczema, the active genotype was also not detected, while the frequency of the low-level genotype SS-6 (54.5%) in patients was significantly increased, and the genotype ІS was found in 5 (45.5%) cases. In the microbial eczema genotype II and SS showed the same frequency - in 4 (21,1%) patients, and the genotype of ІS - in 11 (57,9%) patients (the difference between the groups depending on the diagnosis is not statistically significant - p> 0, 05 by criterion χ2 in all comparisons). At the same time, there is a statistically significant difference in the distribution of genotypes of the TLR1-I602S gene in the groups of patients with individual allergic dermatosis compared with the control of AD - χ2 = 13,645, p = 0.002; TE - χ216,377, p <0,001; ME - χ2 = 10.755, p = 0.005). Analysis of the distribution of polymorphism of the TLR1-I602S gene, depending on the severity of the disease for each group of patients. In patients with BP and TE no significant peculiarities of distribution were detected (p> 0.05 with criterion χ2). In patients with microbial eczema, it should be noted that the active genotype of the TLR1-I602S gene was predominantly found in patients with severe illness (with an IASI score of more than 40 points) - in 3 cases (75%) of the total number with this genotype, but in in general, the distribution of polymorphism, depending on the severity, also did not differ statistically significantly (p> 0.05 with criterion χ2). Conclusions. The revealed features of the distribution of polymorphic alleles in the TLR1-I602S gene in patients with allergic dermatitis can be regarded as an important pathogenetic factor, the development of diseases. The results of the study of the polymorphism of the TLR1-I602S gene in patients with allergic dermatitis may in the future be used to develop early-onset screening techniques and tactics for preventative measures in these patients.