Chronotherapeutic Drug Delivery of Pectin Vs. Guar Gum, Xanthan Gum Controlled Release Colon Targeted Directly Compressed Propranolol Hcl Matrix Tablets

The study has been designed to develop a delayed release matrix tablets by using various natural polymers. The polsaccharide Pectin was used in the formulation Vs. Xanthan gum and Guar gum. The performance of Pectin Vs. other conventional polysaccharides was demonstrated in this work. A model drug Propranolol HCl was incorporated in the formulation design in order to access the drug release profile from the developed matrix system. The polysaccharide based formulation are known for stability issues and manufacturing difficulties. The research was focused on developing industrially relevant direct compression techniques. The polymers were used in different concentration ratios to optimize the best formulation design. The matrix system was evaluated for various quality control parameters. The Carbopol 940 was used as an auxiliary polymer to modify the drug release and to improve the compression characteristics in high speed tablet compression machines. The in vitro studies were performed in developed matrix system in 0.1 N HCl for 1.5- 2h and in pH 6.8 phosphate buffer for 2h and after that pH 7.4 buffer until the maximum amount of drug release. The in vitro drug release profile was analysed various pharmacokinetic models such as zero order, first order, Higuchi, Hixson Crowell, Korsmeyer Peppas model.