Compromised T cell Immunity in Elderly via Naïve T cell AnergyJournal: Journal of Infectious Diseases and Pathogenesis (Vol.1, No. 2)
Publication Date: 2018-05-26
Authors : Anjuman A Ahmed KA Xiang J;
Page : 1-4
Keywords : Immunosenescence; Memory T inflation; Aging; Immune Responses; T Cell Immunity;
Immunosenescence is the term commonly used to describe age-related changes in immune responses with aging. It renders older adults more prone to infectious diseases and age-related diseases like cancer, Alzheimer's, osteoporosis, and autoimmunity. This commentary describes molecular signals that promote imbalance in the ratio of naïve and memory T cells and key findings regarding age-related defects in the function of T cells, and how the functional defect can be compensated in vaccine design.
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Last modified: 2018-12-05 20:45:24