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Compromised T cell Immunity in Elderly via Naïve T cell Anergy

Journal: Journal of Infectious Diseases and Pathogenesis (Vol.1, No. 2)

Publication Date:

Authors : ;

Page : 1-4

Keywords : Immunosenescence; Memory T inflation; Aging; Immune Responses; T Cell Immunity;

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Immunosenescence is the term commonly used to describe age-related changes in immune responses with aging. It renders older adults more prone to infectious diseases and age-related diseases like cancer, Alzheimer's, osteoporosis, and autoimmunity. This commentary describes molecular signals that promote imbalance in the ratio of naïve and memory T cells and key findings regarding age-related defects in the function of T cells, and how the functional defect can be compensated in vaccine design.

Last modified: 2018-12-05 20:45:24