Compromised T cell Immunity in Elderly via Naïve T cell Anergy

Immunosenescence is the term commonly used to describe age-related changes in immune responses with aging. It renders older adults more prone to infectious diseases and age-related diseases like cancer, Alzheimer's, osteoporosis, and autoimmunity. This commentary describes molecular signals that promote imbalance in the ratio of naïve and memory T cells and key findings regarding age-related defects in the function of T cells, and how the functional defect can be compensated in vaccine design.