ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

EVALUATION OF THE TOXICITY OF THE ETHANOLIC EXTRACTS OF THE LEAVES OF HEXALOBUS MONOPETALUS ON THE KIDNEYS AND THE LIVER OF WISTAR RATS

Journal: INTERNATIONAL JOURNAL OF ENGINEERING TECHNOLOGIES AND MANAGEMENT RESEARCH (Vol.5, No. 11)

Publication Date:

Authors : ;

Page : 1-12

Keywords : Hexalobus Monopetalus; Acute Toxicity; Pycnosis; Wistar Rats;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

The overall objective of our study is to evaluate the toxicity of ethanolic extracts of Hexalobus monopetalus leaves on the liver and kidney functions of rats in its therapeutic use. Thus, an ethanolic extract of the leaves was made, then a phytochemical screening of this extract. On the one hand, acute toxicity was measured in a 14-day feeding trial in Wistar rats, and on the other hand, a histopathological study of the organs removed was performed. The phytochemical screens of the ethanolic extracts obtained showed the presence of several phytochemical groups with therapeutic activity. Acute toxicity was noted at 3000 and 5000mg / kg PC doses of rats. Histopathological study revealed hepatic pycnosis at a dose of 5000 mg / kg PC in rats. Finally, no renal damage was observed.

Last modified: 2018-12-10 17:13:48