INTEGRAL ASSESSMENT OF THE RISK FACTORS FOR DIABETIC RETINOPATHY (CONSIDERING GENETIC MARKER) FOR PREDICTING THE PROLIFERATIVE STAGE OF DIABETIC RETINOPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

The work was initiated to perform integral assessment of diabetic retinopathy (DR) risk factors in patients with type 2 diabetes mellitus with genetic markers taken into account. Type 2 diabetes mellitus duration, hyper coagulation, VEGF gene CG genotype, arterial hypertension, compensation (HbAIc≤7%), arterial hypertension in family medical history/ smoking, obesity (BMI > 25kg/m²) and dyslipidemia are the leading DR risk factors in patients with type 2 diabetes mellitus. The lowest, intermediate and highest DR risk was found to score 90.16-123.60, 123.61-157.04 and 157.05-190.48, respectively. VEGF gene CG genotype is found more significant in DR development in patients with type 2 diabetes mellitus than classical risk factors, such as, arterial hypertension, age, diabetes mellitus compensation and dyslipidemia.