SYNTHESIS, ANTI-ARTHRITIC AND ANTIOXIDANT ACTIVITIES OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

A series of novel 2,5-disubstituted-1,3,4-oxadiazoles (2a-j) were synthesized by the reaction of 4-hydroxy benzhydrazide (1) and aromatic aldehydes (2) in the presence of small amounts of ferric chloride in methanol as solvent medium. The synthesized compounds were characterized by various spectrochemical methods including 1H-NMR, IR and MS spectroscopy. The newly synthesized compounds were evaluated for In vitro antioxidant and anti-arthritic activities. Some of the synthesized compounds showed moderate antioxidant and antiarthritic activities.