Role of Green Tea or Bone Marrow Mesenchymal Stem Cells against Skin Damage Induced in Male Albino Rats Exposed to Gamma Radiation

Background: Green tea intake is accompanied with a lower incidence of cancer, cardiovascular disease and neurodegenerative disorders; hence green tea extract has been included as dietary supplement along with other supplements and multivitamins. Aim of the work: This study aimed to investigate the histological and histochemical changes in the skin of male albino rats after exposure to gamma radiation and the possible preventive and therapeutic effect of green tea and Bone Marrow Mesenchymal Stem Cells (BMSCs). Material and methods: The current study was carried out on 40 adult male albino rats. They were divided into 4equal groups. Group one (G1) comprised control rats. Group two (G2) comprised of rats exposed to a single dose of gamma-radiation. Group three (G3) had rats treated with green tea extract in a dose of 35 mg/kg body weight daily one week before and one week after irradiation. Group four (G4) contained rats treated with BMSCs 5 hours after they were irradiated with gamma-radiation. Histopathological and histochemical changes in skin of albino rats were studied. Results: Rats exposed to gamma radiation showed several histological and histochemical changes in their skin. These changes were improved by using either green tea or bone marrow mesenchymal stem cells. BMSCs showed more obvious therapeutic effect than green tea extract. Conclusion: The present work showed that both green tea and BMSCs had preventive and therapeutic effect upon skins of albino rats after they were irradiated with gamma radiation.