The possible regulations through cross-generation transmission on childhood obesity

The findings in humans were supported by the studies in mice, they found that higher thermogenesis and respiration were partially induced by an increase in BAT activation of pups from the fathers exposed to the cold, and the paternal CE (P-CE) could improve systemic metabolism and protected mouse offspring from diet induced obesity. Mechanically, investigators proved that the increase in BAT function of offspring maybe due to the changes in brown adipogenesis and neurogenesis induced by P-CE, and the elevated formation of thermogenic cells in offspring stimulated by P-CE was a cell autonomous manner. Thus, the important findings by Wenfei Sun et al suggest that CE in the father before conception may benefit for systemic metabolism as well as prevent overweight and obesity in the child.