FEATURES OF ENDOMETRIAL STROMA DECIDUALIZATION IN EARLY PREGNANCY LOSS

Background. Decidualization of the endometrial stroma is a multistage process. The immunohistochemical marker of differentiation of decidual cells is desmin. Purpose of the study. The estimation of the prognostic significance of the level of desmin expression in decidual tissue in early miscarriage. Material and methods: Clinico-morphological analysis of 102 cases of miscarriage revealed in women of the Grodno region in 2005 was carried out. Immunohistochemical studies were performed using murine monoclonal antibodies to Desmin receptors (Dako-Cytomation, M076001). Results: The level of desmin expression in the endometrial stroma of patients with miscarriage is significantly higher than in normal pregnancy (p = 0.002). Conclusions: At a positivity level of desmin expression in the endometrial stroma greater than 0.004 it is possible to predict miscarriage with a sensitivity of 100% and a specificity of 100%.