SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

Yusuf Sıcak, Said Nadeem, Bedriye Seda Kurşun Aktar, Emine Elçin Oruç Emre, Mehmet Öztürk, Ayşegül Karaküçük İyidoğan, Mehmet Ali Özler, İbrahim Demirtaş, J Ong Chem Res, 2017, 3 (1), 32-49 Author photo not found Abstract: A series of some pyrazolo derivatives (1-2)(a-f) were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities (IC50) i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 μM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50.